The Molecular Basis of Cancer

The state-of-the-art 2nd Edition of this acclaimed reference explains the principles that form the scientific basis for our understanding of malignant transformation and the pathogenesis and treatment of cancer. Readers will find a broad update on the scientific principles of new diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating the latest advances and newest research, this text also gives thorough descriptions of everything from the basic mechanisms of malignant cells and molecular abnormalities in common cancers to new approaches for cancer therapy. Each chapter discusses the clinical implications for treatment. Numerous examples of the latest clinical interventions help readers understand and assess the products of the biotechnology revolution. IMPORTANT new topics, including chemo-prevention, programmed cell death (apoptosis), genetic counselling, tumour-specific vaccines, genetic abnormalities in the origin and progression of cancer, monoclonal antibody therapy, and molecular predictors of prognosis and response to treatment NEW and revised chapters, covering new basic science knowledge, new approaches to treatment and keeping all information on the cutting-edge of the specialty ABUNDANT illustrations, most of them new, to clarify and explain difficult concepts.